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Neurosciences and Psychiatry

Dr. Lauren DePoy, Ph.D.

Lauren DePoy

Assistant Professor
Office: 183 Block Health Science Building
Tel: 419-383-5266
·¡³¾²¹¾±±ô:Ìýlauren.depoy@utoledo.edu

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Education:

2009: B.S. in Biology and Psychology, Gettysburg College, Gettysburg, PA.
2016: Ph.D. in Neuroscience, Emory University, Atlanta, GA.
2022: Postdoctoral Fellow, University of Pittsburgh, Pittsburgh, PA.

2024: Research Instructor, University of Pittsburgh, Pittsburgh, PA.

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Research Interests:

The long-term goal of my research is to leverage my expertise in behavioral neuroscience to answer complex questions about the role circadian rhythms play in human health and development with the ultimate goal of identifying novel therapeutic targets and improving public health. More specifically, I use animal models to study how circadian disruptions across the lifespan, for example gestation or adolescence, persistently alter behaviors relevant to psychiatric disorders, especially substance use. I use next generation sequencing and varied molecular/cellular approaches in order to investigate the mechanisms underlying these behavioral changes.

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Selected Publications:

  • L.M. DePoy, R. Daut, J.L Brigman, K.P. MacPherson, N. Crowley, O.Gunduz-Cinar, C.L. Pickens, R.Cinar, L.M. Saksida, G. Kunos, D.M. Lovinger, T.J. Bussey, M.C. Camp, A. Holmes. Chronic alcohol produces neuroadaptations to prime striatal learning (2013), Proceedings of the National Academy of Sciences, 110(36):14783-8.
  • L.M. DePoy, K.S. Zimmermann, P.J. Marvar, S.L. Gourley. Induction and reversal of adolescent cocaine-induced habits, Biological Psychiatry, 81(7):595-605.
  • L.M. DePoy, D.D. Becker-Krail, W. Zong, K. Petersen, N. Shah, J.H. Brandon, A.M. Miguelino, G.C. Tseng, R.W. Logan, C.A. McClung. Circadian-dependent and sex-dependent increases in intravenous cocaine self-administration in Npas2 mutant mice, Journal of Neuroscience (2021), 41(5):1046-1058.
  • L.M. DePoy, K. Petersen, W. Zong, K. Ketchesin, R. Matthaei, R. Yin, M.S. Perez, C.A. Vadnie, D.D. Becker-Krail, M.R. Scott, G.C. Tseng, C.A. McClung. Cell-type and sex-specific rhythmic gene expression in the nucleus accumbens, Molecular Psychiatry (2024), 29:3117-3127.
  • L.M. DePoy, C.A. Vadnie, K. Petersen, M. Scott, W. Zong, R. Yin, R. Matthaie, F. Juarez, G.C. Tseng, C.A. McClung. Adolescent circadian rhythm disruption increases reward and risk-taking, Frontiers in Neuroscience (2024), 18:1478508.

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